Risk Factors for the Development of Fistulae and Stenoses in Crohn Disease Patients in the Swiss Inflammatory Bowel Disease Cohort

Background: Fistulae and stenoses represent frequent and severe complications in patients with Crohn disease (CD). Our study aimed to identify risk factors for fistula and stenosis formation in CD patients. Summary: We retrieved data of 1,600 CD patients from the nationwide Swiss Inflammatory Bowel Disease Cohort Study (SIBDCS). The risk for fistulae and stenoses in relation to gender, age at diagnosis, smoking status at diagnosis, and ileal involvement at diagnosis were analyzed. In the multivariate analysis, female gender showed a lower risk for developing perianal and any fistula (risk ratio [RR] 0.721, 95% confidence interval [CI] 0.582–0.893, p = 0.003 and RR 0.717, 95% CI 0.580–0.888, p = 0.002, respectively), and older age at diagnosis showed a lower risk for developing perianal fistula (RR 0.661, 95% CI 0.439–0.995, p = 0.047). Furthermore, ileal involvement was associated Received: November 11, 2016 Accepted: January 19, 2017 Published online: February 25, 2017 PD Dr. med. Michael Scharl Division of Gastroenterology and Hepatology University Hospital Zurich Rämistrasse 100, CH–8091 Zurich (Switzerland) E-Mail michael.scharl @ usz.ch © 2017 S. Karger AG, Basel 2296–9403/17/0014–0172$39.50/0 www.karger.com/iid J.Z. and N.F. contributed equally to this work. D ow nl oa de d by : 54 .1 91 .4 0. 80 9 /1 7/ 20 17 1 1: 01 :5 1 A M